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NCT06430554
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
Conditions: Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
Sex: All
Ages: 18 Years – 85 Years
Healthy volunteers: No
Enrollment: 40
Sponsor: Zhongda Hospital
Location: Zhongda Hospital, Southeast University Nanjing Jiangsu
Summary
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.
Eligibility Criteria
Inclusion Criteria:
1. age ≥18 years
2. Moderate-to-severe ARDS as per the 2023 ESICM definition
3. Undergoing invasive mechanical ventilation
4. Planned prone position based on the attending physicians' decisions
5. Signed informed consent
Exclusion Criteria:
1. age ≥85 years
2. Pregnancy
3. Severe hemodynamic instability (\> 30% increase in vasopressors in the last 6 hours or norepinephrine \> 0.5 µg/kg/min)
4. Clinically suspected elevated intracranial pressure (\>18 mm Hg)
5. Bronchopleural fistula
6. Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
7. Severe hypernatremia (\>170mmol/L)
8. Re-admission of patients already enrolled in this study, or patients who are participating in other studies
Source: ClinicalTrials.gov (NCT06430554). StuddyBuddy aggregates publicly available trial information.
