Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

Conditions: Xerostomia, Graft-versus-host-disease, Sjogren's Disease

Sex: All

Ages: 18 Years – 90 Years

Healthy volunteers: No

Phase: PHASE1

Enrollment: 36

Sponsor: University of Wisconsin, Madison

Location: University of Wisconsin Madison Wisconsin

Summary

The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands. The main question it aims to answer is whether injection of MSCs into salivary glands results in any improvement in dry mouth. Participants will: * have bone marrow collected using a needle * undergo a salivary gland ultrasound * complete questionnaires * receive an injection of the bone marrow cells into a salivary gland

Eligibility Criteria

Inclusion Criteria: * Xerostomia, defined as an unstimulated salivary flow \

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06392711). StuddyBuddy aggregates publicly available trial information.