Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

This clinical trial evaluates the impact of synthetic cooling agents in combustible cigarettes on smoking perceptions and use. Menthol, a natural chemical, is a cooling agent that increases nicotine dependence among smokers. Menthol cigarettes largely contribute to the huge burden that smoking puts on public health. Approximately 43% of adult smokers smoke menthol cigarettes. Regulatory agencies have begun a ban on menthol. In response to the ban, the tobacco industry has introduced synthetic cooling agents as a flavorless replacement to provide the same cooling effects as menthol. Information gained from this trial may help researchers determine how the addition of synthetic cooling agents changes the appeal, abuse liability potential, and respiratory toxicity profile of combustible cigarettes.

Inclusion Criteria: * Aged 21 - 29 years * Established cigarette user * Willing to provide informed consent and abstain from using tobacco products 12 hours prior to the three lab sessions * Read and speak English Exclusion Criteria: * Recently coronavirus disease 2019 positive (COVID-19+) or a recent COVID-19 hospitalization * Self-reported unstable or significant psychiatric conditions * History of cardiac event or distress within the past 3 months * Are currently pregnant, planning to become pregnant, or breastfeeding * Currently attempting to quit using combustible tobacco products * Have suffered from any serious lung disease or infection in the past 30 days