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Completed
NCT06218576
Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )Microinfarctions
Conditions: Acute Cerebral and Cerebellar Cortical Microinfarctions (CMI)
Sex: All
Ages: 18 Years – N/A
Enrollment: 59
Sponsor: Centre Hospitalier Universitaire de Nīmes
Location: CHU de Nîmes Nîmes
Summary
Cerebral cortical microinfarctions (CMI) are frequently observed on MRI and histology studies, especially in elderly patients and in patients with cognitive dysfunction. The majority of these studies analysed chronic cerebral CMI lesions.
The few studies reporting on temporal dynamics of MRI signal of acute cerebral CMI showed very low sensibility for persisting signal changes on follow-up MRI on standard MRI sequences. A retrospective study, analysing follow-up 3T MRI in 25 patients with acute cerebral CMI (defined as ≤10 mm on DWI), showed a chronic cerebral CMI detection rate of only 16% on T2-weighted and 5% on FLAIR imaging after a mean follow-up period of 33 months (with a very wide range of 0.5-142 months). Another 3T MRI study including seven patients showed disappearance of all acute cerebral very small-sized CMI (defined as \
Eligibility Criteria
Inclusion Criteria:
Patients admitted to our stroke centre between February 2021 and June 2023 with the following inclusion criteria:
* age \>18 years,
* initial MRI performed within one week after symptom onset,
* symptomatic brain infarction confirmed by DWI,
* presence of acute cerebral and/or cerebellar CMI
Exclusion Criteria:
* age \< 18 years
Source: ClinicalTrials.gov (NCT06218576). StuddyBuddy aggregates publicly available trial information.