Polyamine Treatment in Elderly Patients With Coronary Artery Disease

Conditions: Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease, Hypertension, Diastolic Dysfunction, Obesity, Metabolic Syndrome, Diabetes Mellitus, Type 2, Dietary Habits, Inflammation, Quality of Life, Cognition Disorder, Cognitive Impairment

Sex: All

Ages: 65 Years – 90 Years

Healthy volunteers: No

Phase: PHASE2

Enrollment: 180

Sponsor: University of Aarhus

Summary

The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.

Eligibility Criteria

Inclusion Criteria: * Age ≥ 65 years * Chronic ischemic heart disease (previous revascularization or myocardial infarction) * Left ventricular ejection fraction of \> 40% And at least two of the following risk factors: * Type 2 diabetes, * Obesity (BMI ≥ 30 kg/m2), * Hypertension, * Previous LVEF \< 40%, * Left atrial volume index ≥ 30 mL/m2 * Left ventricular wall thickness ≥ 1.1 cm. Exclusion Criteria: * Unstable coronary syndrome * Significant and severe cardiac valve disease * Severe peripheral artery disease * Permanent atrial fibrillation * Pacemaker treatment * Chronic kidney disease with eGFR \

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06186102). StuddyBuddy aggregates publicly available trial information.