Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients

The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.

Inclusion Criteria: * Adult (≥ 18 years of age) * Septic shock according to the Sepsis 3 criteria at any time within 12 hours after ICU admission (suspected or confirmed infection, plasma lactate above 2 mmol/L, and infusion of vasopressor/inotrope to maintain mean arterial pressure of 65mmHg or above after receiving adequate fluid resuscitation \[\> 1L within 12 h of screening\]) and need for vasopressors at the time of screening. Exclusion Criteria: * Confirmed or suspected pregnancy * Previous inclusion in the trial * Screened more than 12 hours after ICU admission