Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: PHASE2

Enrollment: 400

Sponsor: University Health Network, Toronto

Summary

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.

Eligibility Criteria

Inclusion Criteria: * Patients \>18 years old * Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee Exclusion Criteria: * TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis * History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency * Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town) * Language difficulties that would impede valid completion of questionnaires * Planned staged bilateral TKA * Treating surgeon deems patient inappropriate for inclusion in trial * Any allergy or sensitivity to milk * Pregnant or planning to become pregnant during the study

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06123715). StuddyBuddy aggregates publicly available trial information.