Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: Yes

Enrollment: 47

Sponsor: Chinese University of Hong Kong

Summary

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: * To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection * To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection * To study the association between plasma levels of selected biomarkers and clinical outcomes

Eligibility Criteria

Inclusion Criteria: * Age ≥ 18 years * Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit * Confirmed AD * the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first * The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery. Exclusion Criteria: * Age \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06065306). StuddyBuddy aggregates publicly available trial information.