← Back to all trials
Recruiting
NCT06007404
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
Conditions: Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes
Sex: All
Ages: 14 Years – 18 Years
Healthy volunteers: Yes
Enrollment: 175
Sponsor: University of Michigan
Location: University of Michigan Ann Arbor Michigan
Summary
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.
Eligibility Criteria
Inclusion Criteria:
* Between 14 and 18 years of age
* Tanner stage 4 or 5 (mature adult stage of puberty)
* Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), overweight (BMI \> 86th percentile) \& \< 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
* For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes
Exclusion Criteria:
* Currently pregnant
* Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
* Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
* Allergies or intolerance to milk, soy, or palm oil
Source: ClinicalTrials.gov (NCT06007404). StuddyBuddy aggregates publicly available trial information.
