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Recruiting
NCT06002477
Attentional Mechanisms in SCD
Conditions: Subjective Cognitive Decline
Sex: All
Ages: 55 Years – N/A
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 80
Sponsor: Vanderbilt University Medical Center
Location: Vanderbilt University Medical Center Nashville Tennessee
Summary
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will result in a greater negative effect on attentional performance (Attention Network Test, ANT) and attention network functioning (EEG) in older adults with greater subjective cognitive concern.
Eligibility Criteria
Inclusion Criteria:
1. age ≥ 55
2. Montreal Cognitive Assessment (MoCA) \> 25 AND Global Deterioration Scale (GDS) rating \< 3
3. Non-smokers
Exclusion Criteria:
1. medical contraindications to the drug challenge
2. primary neurological disorder (such as stroke, epilepsy, etc.)
Source: ClinicalTrials.gov (NCT06002477). StuddyBuddy aggregates publicly available trial information.
