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Active Not Recruiting
NCT05952648
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Conditions: HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 126
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Location: S. Orsola Research Hospital Bologna
Summary
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the first 24 hours from HAP/VAP suspicion, thus allowing early de-escalation.
Eligibility Criteria
Inclusion Criteria:
* Suspicion of HAP/VAP (clinical/radiological/laboratory criteria);
* Availability to perform tracheal aspirates or broncoalveolar lavage within 1 hour from clinical suspicion
* Life expectancy ≥ 48 hours
* Signed written informed consent.
Exclusion Criteria:
* Pregnancy,
* Concomitant participating in other interventional trial
* Refusal to sign informed consent
Source: ClinicalTrials.gov (NCT05952648). StuddyBuddy aggregates publicly available trial information.
