Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Inclusion Criteria: • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1) * Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2) * Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist * Age at least 18 * Able to participate in intraoperative testing * English speaking Exclusion Criteria: * Age less than 18 * Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)