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Terminated
NCT05874011
Prosody Assessment After Right Hemisphere Stroke
Conditions: Right Hemisphere Stroke
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Enrollment: 26
Sponsor: Assistance Publique - Hôpitaux de Paris
Location: Assistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière Paris
Summary
Following a right stroke, more than half of the patients present a communication disorder. These disorders can notably concern prosody. Nevertheless, these remain relatively poorly assessed and characterized. Prosodic alterations in comprehension can result in a disruption of social cognition with potentially important consequences in terms of functional outcome and quality of life of patients. In clinical practice, the investigators do not have a tool that allows us to finely assess these disorders.
Studies in healthy subjects using a processing algorithm capable of arbitrarily manipulating the pitch dynamics of recorded voices have revealed that there are stable internal representations for prosody processing. Initial pilot results show that this method can be used in a clinical context and can indeed identify and accurately measure perceptual processing deficits in prosody following a right stroke. It is necessary to continue the study of this approach with a larger number of subjects in order to have normative data and validate the diagnostic properties of this approach.
Eligibility Criteria
--\>Inclusion Criteria: Inclusion criteria for patients
Patient:
* with a right supratentorial stroke (1st clinical episode of deficit) confirmed on imaging and less than 1 year old at the time of inclusion
* right-handed
* male and female over 18 years of age
* french mother tongue
* affiliated or beneficiary of a social security plan
* free, informed and written consent signed
* Inclusion criteria for control subjects:
Subject:
* no known history of stroke
* right-handed
* over 18 years of age and matched with a case on age (plus or minus 10 years)
* french mother tongue
* affiliated or beneficiary of a social security plan
* free, informed and written consent signed
--\>Exclusion Criteria: Non-inclusion criteria for patients and controls subjects
* comprehension disorders: score less than 10/15 on the BDAE (Boston Diagnostic Aphasia Examination) command execution test
* known dementia
* illiteracy
* severe dysarthria
* psychiatric history requiring hospitalization in a specialized environment for more than two months
* history of brain injury
* major visual or auditory perceptual disorder (hearing loss greater than 40 dB HL)
Source: ClinicalTrials.gov (NCT05874011). StuddyBuddy aggregates publicly available trial information.