C677T Methylenetetrahydrofolate Reductase Mutation

Sex: All

Healthy volunteers: No

Enrollment: 363

Sponsor: Centre Hospitalier Universitaire, Amiens

Summary

To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation. In this longitudinal retrospective study, patients with RM were treated during pregnancy with either: (i) 100 mg/day aspirin and 5 mg/day folic acid (group 1); or the same protocol plus 0.4 mg/day enoxaparin (group 2). An age-matched group of triparous women without RM or thrombophilia was used as the control group (group 3).

Eligibility Criteria

Inclusion Criteria: * patients with three or more consecutive first-trimester miscarriage * Three or more consecutive first-trimester miscatrriages * C677T MTHFR gene mutation Exclusion Criteria: * Patients with the A1298C polymorphism

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05864937). StuddyBuddy aggregates publicly available trial information.