FASHION Fabry Disease Hypertrophic Cardiomyopathy and Infammation

In Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) systemic inflammation recently gained attention as a possible key pathophysiologic process involved in the development of cardiac hypertrophy and progression of the disease. Differences in inflammatory profile between FD and HCM have never been investigated so far.

Inclusion Criteria:Age ≥18 years;Patients with confirmed genetic diagnosis of FD19;Patients with a known diagnosis of sarcomeric HCM adult (with pathogenic mutation in sarcomeric genes identified);Signed informed consent.Exclusion Criteria:Age <18 years;Diagnosis of Autoinflammatory disorders;History of recurrent infections;HIV infection;Active cancer;History of organ transplantation needing chronic immunosuppressor treatment;PregnancyRefusal to sign informed consent to study participation.