Procalcitonin Protocol Use to Guide Antibiotic Therapy Duration in the Intensive Care Unit

To compare and contrast antibiotic use and its effects on patient outcomes before and after the implementation of a PCT protocol in the ICU at Methodist Richardson Medical Center (MRMC).

Inclusion Criteria:● Patients aged 18 years or olderPatients being monitored on the PCT protocolICU location status for at least part of the admissionReceived antibiotics in the ICU for a diagnosis of:Community-acquired pneumoniaHospital-acquired pneumoniaVentilator-associated pneumoniaSepsis and/or septic shockUncomplicated bacteremia with known sourceChronic obstructive pulmonary disorder exacerbationAsthma exacerbationExclusion Criteria:Received antibiotics in the ICU for a diagnosis of:Uncomplicated skin and soft tissue infectionsAbscessEmpyemaBacterial infections that require prolonged antibiotic therapy (e.g., osteomyelitis, endocarditis, tuberculosis, etc.)Intra-abdominal infectionUrinary tract infectionBacterial meningitisEstimated Glomerular Filtration Rate <15 mL/minRequiring renal replacement therapyStatus post cardiac arrest/target temperature management