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NCT05754216
Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve
Conditions: Head and Neck Cancer, Obstructive Sleep Apnea
Sex: All
Ages: 18 Years – N/A
Phase: NA
Enrollment: 50
Sponsor: Vanderbilt University Medical Center
Location: United States
Summary
Published data suggest that the glossopharyngeal nerve innervates pharyngeal musculature important for maintenance of upper airway patency.
The investigators propose a study examining the anatomic variation of the glossopharyngeal nerve and the effect of electrical stimulation on muscle recruitment and upper airway patency.
Eligibility Criteria
Inclusion Criteria:Consenting adults with BMI ≥ 25 and ≤ 40 kg/m2Planned resection of parapharyngeal space (PPS) mass without clinical evidence of cranial nerve function deficits based on physical examinationHistory of moderate-to-severe OSA as confirmed by previous polysomnogram OR high risk for OSA based on STOP-BANG criteria (STOP-BANG score ≥ 3)Exclusion Criteria:Unable to consent for research due to a pre-existing neurologic condition or language barriers as determined by PIHistory of other primary sleep-related breathing disorder (e.g., central, or complex sleep apnea).Previous pharyngeal surgery excluding tonsillectomy (e.g.
cleft palate repair, uvulopalatopharyngoplasty)Prior history of head and/or neck chemoradiation therapyExisting indwelling neurostimulation device (e.g.
pacemaker; spinal, vagal, or hypoglossal nerve stimulator)
Source: ClinicalTrials.gov (NCT05754216). StuddyBuddy aggregates publicly available trial information.