Effects of i-PRF on Non-surgical Periodontal Treatment

Injectable platelet-rich fibrin, a platelet concentrate in a liquid formulation, has been developed to provide clinicians with ease of use alone or in combination with various biomaterials. The low-speed centrifugation method provides a significant advantage to the regeneration process with richer platelets, leukocytes, and growth factors. It also contributes to the wound-healing process by increasing vascularization. It is expected that the application of injectable platelet-rich fibrin into the gingival pocket following subgingival curettage in periodontitis patients will positively affect the results of non-surgical periodontal treatment. For this reason, in this study it was aimed to investigate the early effects of injectable PRF applied into the pocket for root surface biomodification following subgingival curettage in periodontal pockets of 6 mm and above, by evaluating both clinical parameters and inflammatory and healing markers in the gingival groove fluid

Inclusion Criteria:patients with stage 3 grade B periodontitisExclusion Criteria:patients with systemic diseasepregnant and breastfeedingacute or chronic infection in the past 6 monthsUse of systemic antibiotic therapy in the past 6 monthsuse of drugs that can affect periodontal healthreceiving hormone therapysmokersteeth with endodontic lesionsTeeth with class 2 and 3 mobility