European Registry On Plaque ModifiCAtion in the STEMI Population (ROCA-STEMI)

This is an European prospective cohort study from February 2023 until February 2024. The investigators want to analyze the clinical success, efficacy and safety of consecutive patients who presented with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) for de novo heavily calcified culprit lesion using plaque modification devices before stent implantation.

Inclusion Criteria:Age ≥ 18 yearsPatient with a STEMIPrimary percutaneous coronary interventionDe-novo culprit lesion in a native coronary arterySevere calcification of the target lesion or its equivalent (balloon uncrossable or undilatable lesion) (See Definitions 4.4)Mandatory use of a plaque modification device to treat the culprit lesion (See Study device and procedures 4.5)The patient or legal representative signing an informed written consentExclusion Criteria:The target vessel had a stent from a previous PCIThe target lesion was treated as a staged procedurePregnant womenTerminally ill patients