Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage

When given intravenously in doses below 1.2mg/kg, ketamine has been shown to work as an antidepressant. Ketamine is a common induction drug used during general anesthesia. It is known to reduce postoperative pain in this instance. Limited studies have evaluated the effect of a single subanesthetic dosage of ketamine administered as an adjunct to general anesthesia on acute mood states in patients undergoing minor surgery. The aim of this randomized controlled study was to examine if a single intravenous administration of 0.5 mg/kg ketamine given at the induction of propofol/fentanyl anesthesia has an effect on acute mood states before the discharge of women undergoing fractional curettage.

Inclusion Criteria:consecutive patients (>18 years) undergoing fractional curettageExclusion Criteria:American Society of Anesthesiologists' physical status ≥ 3History of psychological disordersUse of drugs affect central nervous systemSubstance abuseChronic painPregnancySeizure disordersCardiovascular, hepatic or renal disease