A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

The purpose of this study is to find out the effects of exercise therapy on indicators of prostate cancer in people with low-risk prostate cancer who are on active surveillance. The exercise therapy in this study will be regular home-based walking sessions on a treadmill, and that therapy will be assigned by an exercise physiologist (a medical professional who studies how exercise affects the human body). Some participants in this study will have the assigned exercise therapy, and some participants will participate in their usual exercise routines. Researchers will compare how the assigned exercise therapy and the usual exercise routines affect indicators of prostate cancer in participants. This study will not provide treatment for prostate cancer.

Inclusion Criteria:Age ≥ 18Men with histologically confirmed localized prostate cancer undergoing active surveillance.Inactive, defined as not meeting the national exercise guidelines for cancer patients (<150 minutes/week of moderate or vigorous exercise)43 as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry (general physical activity screening assessment via smart watch).Screening clearance by an MSK Exercise Physiologist (i.e., review of ECG and PAR-Q)BMI <40 kg/m^2Exclusion Criteria:Enrollment in any other program that may alter the impact of exercise on tumor outcomes (e.g., weight loss program)Any neoadjuvant anticancer treatment of any kind for prostate cancerAny history of systemic anticancer therapyDistant metastatic malignancy of any kindAny other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation