Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm

The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms. Participants will be randomized to different intraoperative heparinization regimens: (i) 50 U/kg intravenous (IV) at 1-h intervals reduced by half to a minimum of 1000 u/h; (ii) 60 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h; (iii) 70 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h. MRI will be performed within 72 h after surgery, and the DWI sequence of MRI will be analyzed. If there is a comparison group: Researchers will compare different intraoperative heparinization protocol groups to see which dose of intraoperative heparin has the best prognosis for use.

Inclusion Criteria:Greater than 18 years old, less than 75 years oldPatients with unruptured intracranial aneurysm were confirmed by DSA.Coagulation function should be normal in the enrolled patients.Exclusion Criteria:Dissection aneurysm, blister aneurysm, moyamoya disease or arteriovenous malformation.Previous use of antithrombotic drugs (including anticoagulant or antiplatelet aggregation drugs).