Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial.

The goal of this double-blind prospective randomized clinical trial is to determine if the effect of intravenous erythropoietin is superior to the effect of intravenous methylprednisolone in cases of toxic optic neuropathy 4 weeks after therapeutic intervention.The main question it aims to answer:• Is there a difference in the visual recovery of toxic optic neuropathies treated with intravenous methylprednisolone in comparison with those treated with intravenous erythropoietin?

Inclusion Criteria:Both genres.Age between 18 and 75 years.Clinical diagnosis of toxic optic neuropathy (afferent pupillary defect, acquired dyschromatopsia, visual loss and bilateral prechiasmatic field defect).Exposure with a temporal relationship of less than two weeks to a known toxicant for the function of the optic nerve.Up to 21 days from symptom onset.Informed consent signature.Exclusion Criteria:History of previous optic neuropathy.History of additional ophthalmological or neurological pathology that has caused permanent visual loss.History of previous treatment with intravenous methylprednisolone or some other experimental treatment since the onset of symptoms.Poorly controlled diabetes mellitus.Poorly controlled systemic arterial hypertension.Hemoglobin >16 mg/dLPatients with a history of thromboembolic event.Patients with a history of coronary heart disease, myocardial infarction or cerebral vascular event.Pregnancy or lactation.