A Comparison of Tissue Adhesive Material and Suture as Wound-closure Techniques Following Carpal Tunnel Decompression

Participants will be randomly assigned to suture-based wound closure (n=50) or tissue adhesive-based wound closure (n=50) with two-component skin adhesive Glubran Tiss 2®. The outcomes will be assessed during the follow-up period at intervals of 2, 6, and 12 weeks postoperatively. A scar assessment will be using the POSAS (Patient and Observer Scar Assessment Scale) and cosmetic VAS (Visual Analog Scale). The VNRS (Verbal Number Rating Scale) will used to assess pain.

Inclusion Criteria: (all of the above)age >18 yearscarpal tunnel syndromeweakness of thumb abductionwith atrophy of the thenarmedian nerve conduction impairment estimated by electromyographyExclusion Criteria: (one or more)threatening haemorrhagic complications (patients with peroral anticoagulation and/or antithrombotic therapy)previous wrist trauma or surgery on the wrist regionanother aetiology of neuropathyprevious allergic reactions (with lidocaine, cyanoacrylate, formaldehyde, tapes, or adhesives)personal or family history of keloids or hypertrophic scarssevere general illness with cachexia