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NCT05746520
Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)
Conditions: Appendicitis Surgery
Sex: All
Ages: 18 Years – N/A
Phase: NA
Enrollment: 400
Sponsor: Wake Forest University Health Sciences
Location: United States
Summary
To demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis
Eligibility Criteria
Inclusion Criteria:Age ≥ 18 yearsPlanned appendectomy (laparoscopic or open)Willing and able to provide informed consentWorking telephone number or reliable method to contact patient after hospital dischargeExclusion Criteria:Unable to consentPregnant WomenPrisonersimmunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage Acquired immunodeficiency syndrome (AIDS)Heart FailureAllergy to BupivacaineUnlikely to comply with treatment or follow-upInpatient consultation for appendicitisClinically suspected sepsis based on Sepsis-3 definitionCurrent use of antibiotics for other indicationsType 1 Diabetes or uncontrolled hyperglycemia
Source: ClinicalTrials.gov (NCT05746520). StuddyBuddy aggregates publicly available trial information.
