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NCT05746377
Metoclopramide in Upper Gastrointestinal Bleed
Conditions: Upper GI Bleeding, Bleeds Gastric, Bleed Ulcer, Hemorrhage Gastric, Hemorrhage; Ulcer
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: 1
Phase: PHASE4
Enrollment: 60
Sponsor: Mercy Health System
Summary
The goal of this clinical trial is to test if metoclopramide can improve effectiveness of endoscopic intervention in upper gastrointestinal (GI) bleeds.
The main questions the investigators hope to answer isDoes metoclopramide lessen the need for repeat endoscopy, interventional radiology intervention or surgery in cases of upper GI bleed?Does metoclopramide improve visibility of the GI walls in cases of upper GI bleed?
Eligibility Criteria
Inclusion Criteria:Age 18 and aboveAdmitted to ER or inpatient services at Javon Bea Hospital MercyHealth RiversidePresent with upper GI bleeding defined as fresh and bright red hematemesis, coffee-ground hematemesis or melenaPlan to undergo EGD within 24 hours since admission or since first symptomsCalculated Glasgow-Blatchford score ≥ 2Exclusion Criteria:Failure to obtain informed consentKnown allergy to metoclopramideConcurrent use of medications known to cause tardive dyskinesia (TD)/extrapyramidal symptoms/neuroleptic malignant syndromeHistory of TD or dystonic reaction to metoclopramidePheochromocytoma, catecholamine-releasing paragangliomasParkinson's DiseaseEpilepsyPregnancy or lactationPrevious gastrectomy
Source: ClinicalTrials.gov (NCT05746377). StuddyBuddy aggregates publicly available trial information.
