Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle

BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.

Inclusion Criteria:healthy male older adultsable to speak and read fluent Lithuanianliving in community during the studyExclusion Criteria:cognitive and neurological disorders (e.g. dementia, stroke, Parkinson, multiple sclerosis)previous lower extremity injurydiabetes mellitus type I or IIno oncologic diseaseno bone fractures in the previous yeardeep vein thrombosiscardiovascular disorders (e.g. congestive heart failure, angina pectoris, uncontrolled arrhythmia, history of myocardial infarction or coronary bypass grafting in the past year)obesity (BMI >30kg/m²)chronic fatigue, chronic headache, or chronic dizzinessineligibility to MRI scanning (e.g. due to claustrofobia or metal implants)The participants should not be engaged in any regular exercise programme during the previous 6 months (according to IPAQ), but able to perform 10 sit-upsAny other consideration that interferes with the study aims and/or risk to the participant, at the discretion of the researcher