CD8 Minibody Repeatability Study

Zr-89 crefmirlimab berdoxam is a Zirconium-89 labelled minibody developed by ImaginAb for full body PET imaging of CD8+ cell distribution (CD8 ImmunoPET). The primary objective of this study is to assess the test-retest repeatability of CD8 immunoPET imaging in oncology patients with stable disease.

Inclusion Criteria:Aged 18 years and abovePatients with at least one imageable primary or metastatic lesion > 1 cm in the lymph nodes or soft tissue excluding bone on the most recent standard of care imaging done within the last 3 monthsCohort 1: Patients with melanoma on single or multiple agent Immune Checkpoint Blockade (ICB) therapy with stable response status following initiation of therapy. Stable disease would be observed over at least 2 consecutive standard of care CT scans (usually done 8-12 weeks apart) after initiation of therapy.Cohort 2: Patients with untreated renal cell carcinoma on active surveillanceWomen of child bearing potential must not be pregnant on study entryParticipants must agree to follow contraceptive advice while on study and for 30 days after ending participation.Exclusion Criteria:Patients with uncontrolled infection or other concurrent malignancies or conditions that may confound interpretation of the scans in the opinion of the investigatorPatients with urinary catheters or stoma bagsPatients who have received a vaccine recently can be included to the study but can only be scanned after a washout period of 2 weeks after the vaccine. If participants have a vaccine after the first PET-CT scan, the second PET-CT scan will be delayed for at least 2 weeks after the vaccinePatients on steroids except those on replacement dose of steroids for adrenal or pituitary insufficiency. Patients requiring steroids as therapy for an unresolved immune therapy related adverse event will be excludedParticipants on immunosuppressive medication e.g. cyclosporine, azathioprine, janus kinase inhibitorsParticipant enrolled into another therapeutic intervention studyAny other contraindication that makes the patient unsuitable to take part in the study in the opinion of the investigatorWomen who are pregnant or breast feedingUnable to provide informed consent