Cohort Study of Adrenogenic Autonomic Cortisol Secretion

To investige the etiology, pathogenesis, diagnosis and treatment of adrenogenic autonomic cortisol secretion in Chinese adults.

Inclusion Criteria:CT examination revealed adrenal nodules (maximum diameter ≥10mm);Serum cortisol > 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST).Exclusion Criteria:Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function.Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy.Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis.Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.