Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke

The purpose of this study is to determine the efficacy and safety of levofloxacin combined with intravenous thrombolysis in treating acute ischemic stroke

Inclusion Criteria:Age 18-65 years.Acute ischemic stroke patients underwent intravenous thrombolysis, treated with ateplase (0.9mg/kg)mRS≤2 before stroke onset, NIHSS≥5 after intravenous thrombolysisSigned and dated informed consent is obtainedLevofloxacin/simulant treatment initiated within 24h of intravenous thrombolysisExclusion Criteria:Patients using glucocorticoids, antiarrhythmic drugs (class I and class III antiarrhythmic drugs: quinidine, procaine amine, lidocaine, phenytoin sodium, verapamil, etc.), and quinolones within 14 days;Patients with other diseases that may aggravate adverse drug reactions, such as ventricular arrhythmias, prolonged QT interval (male: QTc>430ms, female: QTc>450ms), severe cardiac insufficiency (NYHA functional grade ≥ III), myasthenia gravis, peripheral neuropathy, seizures, tendon-related diseases, severe immune system-related diseases, hematological diseases, active hepatitis or cirrhosis, serious respiratory diseases;Abnormal liver and kidney function: glutamic oxaloacetic transaminase or glutamic pyruvic transaminase exceeds 3 times the upper limit of normal; Direct bilirubin or indirect bilirubin more than 3 times the normal upper limit; Blood creatinine exceeds 1.1 times the upper limit of normal; Creatinine clearance rate≤50ml/min; Urea nitrogen≥ 20mg/dL;Ion disorders: hyponatremia (Na<130mmol/L), hypokalemia (K<3.5mmol/L), hyperkalemia (K>5.5mmol/L);Fasting blood glucose lower than 3.9 mmol/L;Patients with symptomatic intracranial hemorrhage confirmed by clinical signs and imaging before randomization;Patients allergy to fluoroquinolones or other antibiotics;Patients with a life expectancy less than 3 months or patients unable to complete the study for other reasons;Not willing to be followed up or poor treatment compliance;Patients who are participating in other clinical studies, or have participated in other clinical studies within 3 months before enrollment, or have participated in this study;Other conditions not suitable for enrollment.