Oral Immunotherapy for Egg Allergy in Children Aged 6 to 16

The aim of the study is to determine the efficacy of a 12-month egg oral immunotherapy (OIT) protocol with a cooked whole egg product including yolk and egg white.We hypothesize that the risk for severe allergic reaction to egg protein is reduced and the diet can partly or completely be normalized.

Inclusion Criteria:Age 6 to 16 yearsElevated spesific serum IgE to egg (> 5 kU/l) and/or positive skin prick to egg allergenPositive oral food challenge for egg or anaphylaxis reaction to egg within the 6 monthsDiet free from egg in any formExclusion Criteria:Age less than 6 years or more than 16 yearsPoor asthma control or uncontrolled asthmaSevere/significant cardiovascular diseaseAutoimmune diseaseMalignancyMedication: beta bloker, angiotensin-converting-enzyme inhibitors (ACE inhibitors), Monoamine oxidase inhibitors (MAOIs)Poor complianceFear of immunotherapyDesensitization to alfa-gal-protein (mammalian meat allergy)