HCC Staging Modified by Tumor Micronecrosis

Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.

Inclusion Criteria:primary and histologically confirmed HCCspatients who underwent curative liver resectionExclusion Criteria:simultaneous presence of other tumorspatients who had received preoperative antitumor therapiesno available surgical specimens for evaluating micronecrosis statusgross tumor necrosis and Nscore = 3