A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.

Inclusion Criteria:Has onset of seizures prior to 3 months of age.Has a minimum weight of at least 10 kg at screening.Has a documented SCN2A variant through genetic testing obtained via a laboratory accredited per Clinical Laboratory Improvement Amendments (CLIA) or College of American Pathologists (CAP) or equivalent.Additional inclusion criteria apply and will be assessed by the study teamExclusion Criteria:Has any clinically significant or known pathogenic genetic variant other than in the SCN2A gene, or a genetic variant that may explain or contribute to the participant's epilepsy and/or developmental disorder.Is taking more than 2 sodium channel blocking anti-seizure medicationsAdditional exclusion criteria apply and will be assessed by the study team