Using of Biomarkers and Blood Culture in Early Detection of Systemic Infections

This work aims to:Validate the performance of CRP, and PCT in early differentiating IFI from bacterial bloodstream infections.Compare the results of CRP and PCT with the results of β-D- glucan. 3. Find the relationship between biomarkers levels [CRP, PCT and β-D- glucan] and the results of blood culture which is the gold standard of diagnosis.

Inclusion Criteria:Patients clinically suspected to have invasive fungal infections such as fever, cough or retrosternal pain, oral mucositis or perianal pain.Drug history of corticosteroids or chemotherapy.Exclusion Criteria:Patients refuse to be part of the study.Patients have no symptoms of systemic infections.Drug history for antimicrobial before blood sample collection.