Forced Oscillations Technique During a Metacholine Test in Children

Asthma is the most common chronic lung disease in children. It affects more than 1 in 10 children in France. The methacholine bronchial challenge test (MBT) is indicated to assess the probability of asthma suggested by clinical symptoms by measuring the forced expiratory volume in one second (FEV1), after inhalation of a cumulative dose of methacholine. In children, the measurement of FEV1 requires a high level of cooperation from the child, which can be the source of false negatives or no result if this is not obtained. The objective of this study is to evaluate if the measurement of the respiratory function by the forced oscillations technique, allows to predict the variation of the FEV1 obtained

Inclusion Criteria:Age between 6 and 16 yearsFEV1 > 60%Child referred to the pulmonary function test laboratory for a non-specific bronchial hyperactivity test with methacholineChild under treatment with inhaled corticosteroids stopped for at least 3 weeksOral consent from the child and at least one of the legal representativesChild affiliated or benefiting from a social security planExclusion Criteria:Use of a short-acting beta-adrenergic bronchodilator within the last 6 hours or anticholinergic bronchodilator within the last 12 hoursUse of a long-acting beta-adrenergic bronchodilator (licensed for use in children) in the past 36 hoursUpper or lower respiratory tract infections within 3 weeks prior to inclusionEpilepsy under treatmentSubject's participation in another interventional study that may alter respiratory functionPatient unable to give consent, vulnerable