UVB-Induced MVP Release in Human Skin

This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.

Inclusion Criteria:Male subjectsAges 21 to 45Skin type: Fitzpatrick Type I or IIExclusion Criteria:Have underlying diseases that could affect wound healingOn medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS [except for low-dose aspirin] or steroids)History of abnormal scarring (e.g., keloids)Should not be on Vitamin C or E supplements for past monthUnable to understand/complete informed consentLarge volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testingRenal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaestheticUse of tanning bends or recent UVB exposure to the areas in the past 3 monthsRecent (within 1 week) use to sunscreen to volar forearms