Evaluation of SNDX-5613 in Participants With Colorectal Cancer and Other Solid Tumors

This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of SNDX-5613 in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy.

Key Inclusion Criteria:Male and female participants aged ≥18 yearsParticipants with metastatic CRC or other solid tumorsEvidence of locally recurrent or metastatic disease based on imaging studies within 28 days of enrollmentCRC participants must have had at least one line of standard-of-care therapy and must have progressed on or been intolerant to, or unable to receive oxaliplatin, irinotecan, and bevacizumab in the advanced/metastatic setting.Other solid tumor participants must have had all approved standard therapies that are available to the participant, unless contraindicated or intolerable.Participants must have experienced documented unequivocal progressive disease by either RECIST v1.1 or clinical assessment, or experienced unacceptable toxicity with their prior therapy.Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 1If receiving radiation therapy, has had a 2-week washout period following completion of the treatment prior to receiving the first study drug dose and continues to have at least 1 measurable lesionAt least 42 days since prior immunotherapy, including tumor vaccines and checkpoint inhibitors, and at least 21 days since receipt of chimeric antigen receptor therapy or other modified T-cell therapyAdequate bone marrow, renal, cardiac, and liver functionKey Exclusion Criteria:Participant has a prior history of malignant bowel obstruction requiring hospitalization in the 6 months prior to enrollmentParticipant has a history of uncontrolled ascites, defined as symptomatic ascites and/or repeated paracenteses for symptom control in the past 3 monthsDetectable human immunodeficiency virus (HIV) viral load within the previous 6 months. Participants with a known history of HIV 1/2 antibodies must have viral load testing prior to study enrollmentHepatitis B and/or CAny of the following within the 6 months prior to study entry: myocardial infarction, uncontrolled/unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), life-threatening, uncontrolled arrhythmia, cerebrovascular accident, or transient ischemic attackCorrected QT interval (QTc) >450 millisecondsAny gastrointestinal (GI) issue of the upper GI tract likely to affect oral drug absorption or ingestion (for example, gastric bypass, gastroparesis)Cirrhosis with a Child-Pugh score of B or CBrain metastasis except for those participants who have completed definitive therapy, are not on steroids, have a stable neurologic status for at least 4 weeks after completion of the definitive therapy and steroids, and do not have neurologic dysfunction that would confound the evaluation of neurologic and other adverse events (AEs)History of or any concurrent condition, therapy, laboratory abnormality, or allergy to excipients that in the Investigator's opinion might confound the results of the study, interfere with the participant's ability to participate for the full duration of the study, or not be in the best interest of the participant to participateParticipant has received prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to study baseline or who has not recovered (that is, ≤Grade 1 or at baseline) from AEs related to a previously administered agent.Participation in another therapeutic interventional clinical study in which an investigational agent was administered within 30 days before starting SNDX-5613Participant has received a transfusion of blood products or administration of colony stimulating factors within 4 weeks of the first dose of the study drugParticipant has another known additional malignancy that is progressing or requires active treatment (excluding adequately treated basal cell carcinoma, squamous cell of the skin, cervical intraepithelial neoplasia/cervical carcinoma in situ or melanoma in situ or ductal carcinoma in situ of the breast). Prior history of other cancer is allowed, if there is no active disease within the prior 5 years