Effects of the Contraceptive Implant in Women With Sickle Cell Disease

The objective of this study is to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with SCD.

Inclusion Criteria:Female aged 18-45Diagnosis of sickle cell disease (SS or SB0)Report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 monthsWilling to discontinue any hormonal contraception at the time of enrollment. Washout period of 1 month required for all hormonal contraception prior to enrollment in the study.Access to a device with text messaging capabilityMust be able to read and understand EnglishWilling to comply with study proceduresExclusion Criteria:SC DiseaseUse of Depo Provera in the past 6 monthsChanges to sickle cell medications in the past 3 monthsContraindications to use of Nexplanon device as per clinical standardsCurrently pregnant or pregnant within the last month or seeking to become pregnantCurrently breastfeeding