Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)

Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia. Previous studies only focused on the hemodynamics after preoperative fluid infusion. Pre-operative fluid infusion can reduce the incidence of post-operative complications by preventing post-induction hypotension. The patients who is 18 years or older and undergo elective non-cardiac surgery with general anesthsia will be enrolled. The intervention is intravenous infusion of colloids or crytalloids before induction of general anesthesia. The primary outcome is the incidence of post-operative complications within 30 days.

Inclusion Criteria: * 18 years or older * ASA I-III * Undergoing elective non-cardiac surgery under general aneathesia Exclusion Criteria: * Allergic to colloids * Severe heart diseases ( Ejection Fraction lower than 35%) * Presence of renal failure pre-operatively (defined as eGFR \< 30 mL/min/1.73 m2 and/or patient receiving renal replacement therapy) * Morbid obesity (BMI \> 37.5kg/m2 or \> 32.5kg/m2 with metabolic diseases) * Presence of a coagulopathy at screening (defined as platelet count \< 100 × 109/L and/or a prothrombin time \< 70% and/or an activated partial thromboplastin time (aPTT) \>35 s and/or fibrinogen \160 mmol/L or \