Efficacy of Prophylactic Negative Pressure Wound Therapy (NPWT)

The role of prophylactic negative pressure wound therapy (NPWT) is promising in reducing wound-related complications. However, the prophylactic use of NPWT in reducing wound complications in patients who underwent conventional open harvesting of the great saphenous vein has been under-investigated compering with other surgical approaches.Therefore, this study aims to assess the effect size of the prophylactic NPWT in preventing wound dehiscence in high-risk patients who underwent conventional open harvesting of the great saphenous vein as a conduit for coronary artery bypass.

Inclusion Criteria:Adult patients (aged ≥ 50 years)Diagnosis of Diabetes (both type 1 and 2) as comorbidity with anamnesis during the last year of poor glycemic control (HbA1C >7.5%)BMI ≥ 25 Kg/m2Exclusion Criteria:Cognitive impairmentAnamnesis of non-heling woundsWagner grade 2-5 foot woundOsteomyelitisPregnancyContraindication to use PICO7 described previously.