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NCT05722951
Metformin Efficacy and Safety in Epileptic Patients
Conditions: Epilepsy
Sex: All
Ages: 18 Years – 65 Years
Phase: PHASE3
Enrollment: 60
Sponsor: Tanta University
Location: Egypt
Summary
The goal of this clinical trial is to Evaluating Metformin Efficacy and Safety when Co-administered with Antiepileptic Drugs in Patients with Seizures.
The main question it aims to answer is:Does metformin have beneficial effect on epileptic patients?How metformin can affect epileptic patient's health?Participants will be divided into 2 groups (control group and treatment group)Control group will receive standard treatment (levetiracetam).Treatment group will receive standard treatment (levetiracetam) + metformin
Eligibility Criteria
Inclusion Criteria:Age: 18 - 65 years oldObese and overweight patients with body mass index (BMI) ≥ 25.Exclusion Criteria:Patients with severe liver damage or kidney disease (eGFR below 45mL/min/1.73 m²).Patients having acute or chronic disease which may cause tissue hypoxia and increase the risk of lactic acidosis (e.g.
cardiac/respiratory failure, recent myocardial infarction).Patients who are already taking metformin.Diabetic patients.Cancer patients.Pregnant or lactating women.Patients with known hypersensitivity to the drug.
Source: ClinicalTrials.gov (NCT05722951). StuddyBuddy aggregates publicly available trial information.