L-Cit and Endothelial Function

The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease. This study will extend current body of knowledge and will investigate the effect of L-Citrulline on brain vascular function.

Inclusion Criteria:Age 21-45 and ≥55-90 years of ageAdequate hearing and visual acuity to participate in the examinationsAbility to read and write in EnglishCompetence to provide informed consentExclusion Criteria:Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancerCerebrovascular accident other than TIA within 60 days prior to Visit 0Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuseTreatment with other Citrulline enhancers (L-Arginine, L-Citrulline Malate) within 4 weeks prior to Visit 0Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol