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Completed
NCT05718830
Selecting Specific Bio-markers and Researching Mechanisms of Immune Regulation From Inhalation Injury and Traumatic Lung Injury Based on Single Cell Sequencing Technology
Conditions: Traumatic Lung Injury, Inhalation Injury
Sex: All
Ages: 18 Years – 90 Years
Healthy volunteers: 1
Enrollment: 21
Sponsor: Changhai Hospital
Location: China
Summary
The goal of this observational study is to profile the circulating immunological traits of patients with traumatic lung injury (TLI) and inhalation injury (ILI),providing a new direction for the depth research of the pathogenesis, and providing new immune-related targets for diagnosis of the severity of lung injury and treatment.The investigators performed scRNA-seq of neutrophil and peripheral blood mononuclear cells (PBMCs) from 10 ml fresh circulating blood from 3 patients with TLI and 3 patients with ILI at longitudinal timepoints,as well as peripheral blood from 3 health controls(HCs).
Eligibility Criteria
Inclusion Criteria:Lung injury caused by burn trauma is confirmed, and the patient is hospitalized within 24 hours after burn or trauma (the clinician can make a definite diagnosis of lung injury based on the comprehensive judgment of the patient's etiology, history, clinical manifestations, blood gas analysis, laboratory tests and imaging);Patients with inhalation injury caused by head, face and neck burns or inhalation injury combined with multiple body burns < 30%;Patients with simple inhalation injury;The normal control group should have no smoking history and be normal population;According to the provisions of Good Clinical Practice(GCP), the informed consent has been obtained and the informed consent has been signed to volunteer for the test.Exclusion Criteria:Basic pulmonary diseases like chronic obstructive pulmonary disease (COPD), asthma and et al;Severe organ dysfunction;Autoimmune diseases;Tumor;Severe infection;Pregnant or nursing women;Fatal or life-threatening events caused by trauma;Any history which may interfere the results or increase the risk of patients judged by researchers.
Source: ClinicalTrials.gov (NCT05718830). StuddyBuddy aggregates publicly available trial information.
