Characterization of the Plasma Metallomic Profile to Acute Exercise in Healthy Men and Women (METALEXO)

Among the various trace elements playing a key role in physical performance, iron is probably one of the most studied in the last 30 years. Iron is an essential component of both hemoglobin and myoglobin allowing an optimal oxygen delivery to organs, especially to skeletal muscle. Iron also plays a major role in the mitochondrial respiratory chain, as well as in the activity of numerous enzymes. Recent studies support the existence of a strong interaction between the iron metabolism and the other non-ferrous trace elements including among others zinc, copper or cobalt. The latter, but also other trace element metals could thus play an important role in physical performance. The finality of this project is thus 1) to determine the variations of plasma iron and non-ferrous metals in response to an acute exercise, 2) better understand the interactions between all these metals, 3) to determine if such responses to exercise are different or not depending on sex.

Inclusion Criteria:BMI between 18 and 25 kg/m²Non smoker150-300 min of moderate physical activity or 75-150 min of intensive physical activity per week.Written informed consentExclusion Criteria:Iron metabolism disorders (i.e. genetic hemochromatosis, thalassemia, anemia)Cardiovascular risksMetabolic diseases (e.g.diabetes)Use of non-steroidal anti-inflammatory drugs or aspirinSimultaneous participation in another research involving the human person or having recently participated in another research for which the exclusion period has not been completed.