Precision Exercise Therapeutics (PET-pilot)

The aim of this randomized cross-over study is to collect information for the design of a precision exercise therapy cohort that will predict what modality of physical activity a physically inactive individual with overweight should perform to increase insulin sensitivity given their unique biology, environment, and context.

Inclusion Criteria:BMI>25Age> 40 yearsInactivity, defined as < 1,5 hours of structured physical activity pr. week at moderate intensity and cycling < 30 minutes/5 km pr. day at moderate intensity (moderate intensity = out of breath but able to speak)Exclusion Criteria:• HbA1c>53 mmol/molUncontrolled hypertensionUncontrolled hyperlipidemia,Known hyperthyroid diseaseEndocrine disorders causing obesityKnown autoimmune diseaseUnstable cardiovascular diseaseGlucose lowering medications except for low dose metformin (=<1000 mg/day)Current treatment with anti-inflammatory medication, unless pain killers without prescriptionNo participation in other research intervention studiesPregnancy/considering pregnancy within the study periodConditions countering exercise