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Completed
NCT05717881
Impact of Poplar Propolis on Metabolic Disturbances of Insulin Resistance
Conditions: Insulin Resistance
Sex: All
Ages: 18 Years – 60 Years
Phase: NA
Enrollment: 9
Sponsor: Aix Marseille Université
Location: France
Summary
Propolis, a natural resinous mixture rich in polyphenols, produced by bees from a variety of plant sources, has shown significant therapeutic effects and may prevent the development of certain chronic diseases.
Current evidence supports the beneficial effect of these bioactive phytochemicals on the management of type 2 diabetes mellitus (T2DM) and other chronic diseases.
The objective of this study is to evaluate the effect of poplar propolis extract powder (PPEP) on glucose homeostasis and other clinical parameters in insulin-resistant patients (diagnosed by HOMA-IR index > 1.85 for men and > 2.07 for women).
Eligibility Criteria
Inclusion Criteria:Body mass index (BMI) ≥ 30 kg/m2Insulin resistance defined as a HOMA-IR index > 1.85 for men and > 2.07 for womenExclusion Criteria:Presence of diabetesRecent weight change (≥ 5% in the last 3 months)Documented allergy to bee products and/or fish productsPositive serology for human immunodeficiency virus or hepatitisHigh blood pressureElevated transaminases (AST > 40 IU/L ; ALT > 45 IU/L)Low creatine clearance (estimated glomerular filtration rate < 90 ml/min)Interfering treatment (cholesterol-lowering treatment, intestinal absorption modulating treatment, absorption modulating treatment and/or insulin sensitivity)Gastrointestinal tract surgeryPregnancy and / or lactation.
Source: ClinicalTrials.gov (NCT05717881). StuddyBuddy aggregates publicly available trial information.
