Adductor Canal Block in Total Knee Arthroplasty

The purpose of this study is to evaluate whether adding ketamine to bupivacaine is superior to bupivacaine alone in terms of providing better pain control for 48 hours postoperatively after TKA.

Inclusion Criteria:The subject is scheduled for elective primary unilateral TKA.The subject is ≥ 18 years and ≤ 80 years.Both sexes.The subject's primary anesthesia care team has planned for a spinal anesthesia.The patient agrees to receive an adductor canal block.ASA class 1-3.Exclusion Criteria:Subject is < 18 years of age or >80 years of age.Subject is known or believed to be pregnant.Significant pre-existing neuropathy on the operative limb.Significant renal, cardiac or hepatic disease.ASA class 4-5.