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NCT05712772
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Conditions: Depression in Adolescence, Depression in Adults
Sex: All
Ages: 12 Years – 30 Years
Healthy volunteers: No
Phase: NA
Enrollment: 80
Sponsor: University of Pittsburgh
Location: Western Psychiatric Hospital Pittsburgh Pennsylvania
Summary
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are:
* Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals?
* Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults?
Participants will complete:
* A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses.
* A pupillometry test of sensitivity to blue vs red light
* Clinical interviews and surveys
* Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\]
* Home sleep tracking with sleep diary and actigraphy for one week
Eligibility Criteria
Inclusion Criteria:
* Elevated Depressive Symptoms \[PHQ9≥5 And (Item 1≥1 or Item 2≥1)\]
* (If \
Source: ClinicalTrials.gov (NCT05712772). StuddyBuddy aggregates publicly available trial information.