Fatigue, Depressive Disorders and Insomnia in Adult Patients With Marfan Syndrome and Ehlers-Danlos Syndrome: Survey

The goal of this observational study is to describe and assess the presence of perceived fatigue in subjects with MFS and EDS. the main question it aims to answer through the FSS instrument is:The relationship of fatigue with physical and psychological characteristics, the presence of depressive disorders and insomnia.

Inclusion Criteria:Subjects aged 18 or greater with clinical and/or genetic diagnosis of Marfan syndrome;Subjects aged 18 or greater with clinical and/or genetic diagnosis of Ehlers-Danlos syndrome;Signed informed consent.Exclusion Criteria:Functional physical limitations (handicap, impairment, disability) to activities of daily living;Clinically significant heart or lung diseases.