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Completed
NCT05712148
Spheroidal Mesenchymal Stem Cells in Retinitis Pigmentosa
Conditions: Retinitis Pigmentosa, Stem Cell Transplant
Sex: All
Phase: PHASE1, PHASE2
Enrollment: 15
Sponsor: Acibadem University
Location: Turkey
Summary
Purpose: This prospective clinical case series aimed to evaluate the effect of suprachoroidal implantation of mesenchymal stem cells (MSCs) in the form of spheroids as a stem cell therapy for retinitis pigmentosa (RP) patients with relatively good visual acuity.Methods: Fifteen eyes of 15 patients with RP who received suprachoroidal implantation of MSCs in the form of spheroids were included.
Best corrected visual acuity (BCVA), 10-2 and 30-2 visual field examination and multifocal electroretinography (mfERG) recordings were recorded at baseline, postoperative first, third- and sixth-months during follow-up.
Eligibility Criteria
Inclusion Criteria:1) Clinical and genetic diagnosis of Retinitis PigmentosaExclusion Criteria:Coexisting ocular pathology that may affect visual acuity, visual field and retinal morphology such as glaucoma, uveitis, previous vitreoretinal surgery,Coexisting cataract that may affect mfERG, visual field and/or ocular imaging,Refractive error that may affect measurements higher than +6.00D, lower than -6.00DCoexisting systemic diseases that may affect visual function such as diabetes, vasculitis, rheumatological diseases and chronic immunosuppressive use,Periocular injection of platelet-rich blood and transcorneal electrical stimulation in previous 6 months and 6) previous ocular surgery
Source: ClinicalTrials.gov (NCT05712148). StuddyBuddy aggregates publicly available trial information.
